The liquid layering of pellets is a process performed in a Roto-Processor. The active is first sprayed onto cores, then dried and formed before the next layer is applied.

The powder layering of pellets is a process performed in a Roto-Processor. The active is introduced in a solid form, while the binder is introduced in a liquid form. Afterwards the material is dried and formed before the next layer is applied.

For wet granulation pelletisation - the active is mixed with microcristalline cellulose, this mixture is than granulated with water or an organic solvent - simultaneously a spheronisation of takes place.

Melt granulation pelletisation is performed in a mixer/granulator with the assistance of a special impeller - after the melting of the active and binder mixture, pellets are formed.

In a three-step process - a wet mixture of powders is first created then extruded into extrudates, which are then broken and rounded in the Spheronizer.